Requires Prescription (YES/NO)
How it works
Meropenem exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in Gram-positive and Gram-negative bacteria through binding to penicillin-binding proteins (PBPs). Meropenem binds to PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.
USAGE AND SAFETY
Common : Thrombocythemia, headache, diarrhea, vomiting, nausea, abdominal pain, increased transaminases, increased blood alkaline phosphatase, increased blood lactate dehydrogenase, rash, pruritis, inflammation and pain.Uncommon : Oral and vaginal candidiasis, eosinophilia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, hemolytic anemia, angioedema, anaphylaxis, paraesthesiae, antibiotic-associated colitis, increased blood bilirubin, urticaria, toxic epidermal necrolysis, Stevens Johnson syndrome, erythema multiforme, increased blood creatinine & urea, thrombophlebitis and pain at the injection site.Rare : Convulsions.
Probenecid , Valproic Acid , Oral Anti-coagulants.
Meropenem I.V is indicated for the treatment of the following infections in : Adults and children over 3 months of age: • Severe pneumonia including hospital and ventilator-associated pneumonia • Broncho-pulmonary infections in cystic fibrosis • Complicated urinary tract infection • Complicated intra-abdominal infections • Intra- and post-partum infection • Complicated skin and soft tissue infections • Septicemia • Management of febrile neutropenia • Acute bacterial meningitis.
When not to Use
Meropenem is contraindicated in patients:- With known hypersensitivity to meropenem or to any excipient of the product.- Hypersensitive to any other carbapenem antibacterial agent.- Who have demonstrated anaphylactic reactions to any other type of ß-lactams antibacterial agent (e.g. Penicillins or cephalosporins).
The selection of meropenem to treat an individual patient should take into account the appropriateness of using a carbapenem antibacterial agent based on factors such as severity of the infection, the prevalence of resistance to other suitable antibacterial agents and the risk of selecting for carbapenem-resistant bacteria.
As with all beta-lactam antibiotics, serious and occasionally fatal hypersensitivity reactions have been reported. Before initiating therapy with meropenem, careful inquiry should be made concerning previous hypersensitivity reactions to beta-lactam antibiotics. If a severe allergic reaction occurs, meropenem should be discontinued and appropriate measures should be taken.
Seizures have infrequently been reported during treatment with carbapenems, including meropenem.
Hepatic function should be closely monitored during treatment with meropenem due to the risk of hepatic toxicity (hepatic dysfunction with cholestasis and cytolysis).
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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