Requires Prescription (YES/NO)
How it works
Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in the formation of defective cell walls and cell death.
USAGE AND SAFETY
Hypersensitivity reactions such as allergic skin reactions and anaphy lactic reactions, secondary infections with yeast, fungi or resistant organisms as well as changes in blood cell counts.Mycosis of the genital tract, neutropenia, leucopenia, eosinophilia, thrombocytopenia, anaemia (including haemolytic anaemia), slight prolongation of prothrombin time, anaphy lactic (e.g. bronchospasm) and anaphy lactoid reactions, headache, dizziness, Increase in serum liver enzymes (AST, ALT, alkaline phosphatase), rigors and pyrexia.
Calcium containing IV solutions , oral hormonal contraceptives..
It is indicated for the treatment of the following infections due to susceptible organisms. Such infections include: Lower respiratory tract infections Acute bacterial otitis media Skin and skin structure infections Urinary tract infections (complicated and uncomplicated etc.
When not to Use
Ceftriaxone is contraindicated in patients with:- Hypersensitivity to ceftriaxone or to any of the cephalosporins.- Previous immediate and/or severe hypersensitivity reaction to penicillin or to any other type of beta-lactam drug.- Premature newborns up to a corrected age of 41 weeks (weeks of gestation + weeks of life) .
Before therapy with ceftriaxone is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, Penicillins or other drugs.
An immune mediated hemolytic anemia has been observed in patients receiving cephalosporin class antibacterials including Ceftriaxone.
Patients with impaired vitamin K synthesis or low vitamin K stores (e.g, chronic hepatic disease and malnutrition) may require monitoring of prothrombin time during Ceftriaxone treatment. Vitamin K administration (10 mg weekly) may be necessary if the prothrombin time is prolonged before or during therapy.
Prolonged use of Ceftriaxone may result in overgrowth of nonsusceptible organisms. Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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